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Reteplase fibrinolysis

Rapilysin - Retavase - reteplase

Acute myocardial infarction

All type of patients: 3 trials - GUSTO III - INJECT - RAPID-2

reteplase vs accelerated t-PA

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
short term death	1.02 [0.89 1.16]	p=1.00	0	15383	2	GUSTO III,RAPID-2,
reinfarction	1.05 [0.37 2.96]	p=1.00	0	324	1	RAPID-2,
Cardiovascular death	no data
Long term death	no data
Haemmorhagic stroke	0.61 [0.10 3.71]	p=1.00	0	324	1	RAPID-2,
stroke (fatal and non fatal)	0.91 [0.70 1.17]	p=1.00	0	15383	2	GUSTO III,RAPID-2,
Major bleeding	0.86 [0.64 1.16]	p=1.00	0	15383	2	GUSTO III,RAPID-2,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

reteplase vs streptokinase

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
short term death	0.95 [0.80 1.13]	p=1.00	0	6010	1	INJECT,
reinfarction	no data
Cardiovascular death	no data
Long term death	no data
Haemmorhagic stroke	no data
stroke (fatal and non fatal)	1.23 [0.76 2.00]	p=1.00	0	6010	1	INJECT,
Major bleeding	no data

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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