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Vesnarinone phosphodiesterase III inhibitors

OPC-8212 - OPC 8212 - vesnarinone

Heart failure

All type of patients: 3 trials - OPC-8212 MRG - VEST - VSG

Vesnarinone vs placebo

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
Sudden death	1.19 [0.95 1.48]	p=1.00	0	4310	2	VEST,VSG,
Worsening heart failure	0.91 [0.79 1.05]	p=1.00	0	4393	3	OPC-8212 MRG,VEST,VSG,
Transplantation	0.46 [0.17 1.23]	p=1.00	0	477	1	VSG,
Arrhythmia	2.83 [0.44 18.13]	p=1.00	0	560	2	OPC-8212 MRG,VSG,
Vertigo	2.53 [0.10 64.06]	p=1.00	0	83	1	OPC-8212 MRG,
Death from any cause or hospitalization for heart failure	no data
myocardial infarction (fatal and non fatal)	1.21 [0.56 2.59]	p=1.00	0	4310	2	VEST,VSG,
cardiac death	1.06 [0.89 1.25]	p=1.00	0	4310	2	VEST,VSG,
All cause death	1.09 [0.92 1.28]	p=1.00	0	4393	3	OPC-8212 MRG,VEST,VSG,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

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