| vs primary intervention | No demonstrated result suggested Initial TIMI 3 flow by 190% (not demonstrated) suggested urgent target vessel revascularisation by 356% (not demonstrated) suggested Non fatal MI by 82% (not demonstrated) suggested All cause death by 58% (not demonstrated) | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| Initial TIMI 3 flow | 2.90 [2.29 3.66] | p=0.04 | 0 | 1667 | 1 | ASSENT-4 PCI (Van de Werf), | | Final TIMI 3 flow | 0.99 [0.73 1.33] | p=1.00 | 0 | 1667 | 1 | ASSENT-4 PCI (Van de Werf), | | urgent target vessel revascularisation | 4.56 [2.11 9.87] | p=0.04 | 0 | 1661 | 1 | ASSENT-4 PCI (Van de Werf), | | Non fatal MI | 1.82 [1.09 3.03] | p=0.04 | 0 | 1651 | 1 | ASSENT-4 PCI (Van de Werf), | | All cause death | 1.58 [1.00 2.49] | p=0.04 | 0 | 1664 | 1 | ASSENT-4 PCI (Van de Werf), | | Major bleeding | 1.26 [0.81 1.96] | p=1.00 | 0 | 1667 | 1 | ASSENT-4 PCI (Van de Werf), |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
| Eptifibatide + tenecteplase vs primary intervention | No demonstrated result suggested Initial TIMI 3 flow by 116% (not demonstrated) | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| Initial TIMI 3 flow | 2.16 [1.03 4.52] | p=0.04 | 0 | 146 | 1 | ADVANCE-MI, | | Final TIMI 3 flow | no data | | urgent target vessel revascularisation | no data | | Non fatal MI | 0.56 [0.05 6.29] | p=1.00 | 0 | 146 | 1 | ADVANCE-MI, | | All cause death | 12.28 [0.67 226.28] | p=1.00 | 0 | 146 | 1 | ADVANCE-MI, | | Major bleeding | 2.37 [0.95 5.92] | p=1.00 | 0 | 146 | 1 | ADVANCE-MI, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
| tenecteplase vs primary intervention | No demonstrated result suggested Initial TIMI 3 flow by 390% (not demonstrated) | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| urgent target vessel revascularisation | 1.04 [0.06 16.82] | p=1.00 | 0 | 212 | 1 | GRACIA (Fernandez-Aviles,), | | Initial TIMI 3 flow | 4.90 [2.37 10.12] | p=0.04 | 0 | 189 | 1 | GRACIA (Fernandez-Aviles,), | | Final TIMI 3 flow | 1.04 [0.46 2.35] | p=1.00 | 0 | 189 | 1 | GRACIA (Fernandez-Aviles,), | | Non fatal MI | 1.04 [0.06 16.82] | p=1.00 | 0 | 212 | 1 | GRACIA (Fernandez-Aviles,), | | All cause death | 0.62 [0.15 2.68] | p=1.00 | 0 | 212 | 1 | GRACIA (Fernandez-Aviles,), | | Major bleeding | 0.35 [0.04 3.38] | p=1.00 | 0 | 212 | 1 | GRACIA (Fernandez-Aviles,), |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
