Streptokinase fibrinolysis

Acute myocardial infarction

>6h from onset of symptoms:  1 trials  - EMERAS (7-12h)

streptokinase vs placebo

No demonstrated result

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All type of patients:  8 trials  - ISAM - ISIS-2 (SK) - Western Washington Intravenous Trial - GISSI I - GUSTO tPA-SK Hiv - EMERAS (all delay) - ISIS 2 pilot - EMERAS (7-12h)

streptokinase vs placebo

No demonstrated result

Major bleeding by 238% (harmful effect)

suggested short term death by 18% (not demonstrated)

suggested Long term death by 9% (not demonstrated)

t-PA + streptokinase vs streptokinase

No demonstrated result

Facilated PCI:  2 trials  - SAMI (O’Neill) - PRAGUE (Widimisky)

streptokinase vs primary intervention

No demonstrated result

suggested urgent target vessel revascularisation by 769% (not demonstrated)

suggested Major bleeding by 830% (not demonstrated)

Late reperfusion:  1 trials  - EMERAS (7-12h)

streptokinase vs placebo

No demonstrated result

Pulmonary embolism

All type of patients:  3 trials  - Tibbutt - Ly - Jerjes-Sanchez

streptokinase vs no fibrinolysis

No demonstrated result

Venous thrombosis

All type of patients:  7 trials  - Arneson - Common - Elsharawy - Schulman - Tsapogas - Kakkar (streptokinase) - Schweizer (systemic SK)

streptokinase vs no fibrinolysis

No demonstrated result

suggested Any improvement in venous patency (early) by 1115% (not demonstrated)

suggested Complete clot lysis (early) by 203% (not demonstrated)

suggested Complete clot lysis (late) by 277% (not demonstrated)