streptokinase vs no fibrinolysis | No demonstrated result suggested Any improvement in venous patency (early) by 1115% (not demonstrated) suggested Complete clot lysis (early) by 203% (not demonstrated) suggested Complete clot lysis (late) by 277% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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Mortality (early) | 1.04 [0.28 3.85] | p=1.00 | 0 | 182 | 5 | Arneson,Common,Elsharawy,Schulman,Kakkar (streptokinase), | Pulmonary embolism (early) | 0.60 [0.12 3.10] | p=1.00 | 0 | 132 | 4 | Arneson,Elsharawy,Schulman,Kakkar (streptokinase), | Bleeding (early) | 1.52 [0.67 3.45] | p=1.00 | 0 | 181 | 5 | Arneson,Common,Elsharawy,Schulman,Kakkar (streptokinase), | Any improvement in venous patency (early) | 12.15 [7.16 20.61] | p=0.04 | 0 | 141 | 4 | Arneson,Common,Elsharawy,Kakkar (streptokinase), | Complete clot lysis (early) | 3.03 [1.10 8.31] | p=0.04 | 0 | 129 | 4 | Common,Elsharawy,Schulman,Kakkar (streptokinase), | Stroke/intracerebral bleeding (early) | 1.27 [0.27 6.06] | p=1.00 | 0 | 215 | 6 | Arneson,Common,Elsharawy,Schulman,Tsapogas,Kakkar (streptokinase), | Leg ulceration (late) | 0.32 [0.03 3.56] | p=1.00 | 0 | 71 | 2 | Arneson,Schulman, | Mortality (late) | 1.33 [0.26 6.85] | p=1.00 | 0 | 42 | 1 | Arneson, | Post-thrombotic syndrome (late) | 0.47 [0.11 2.01] | p=1.00 | 0 | 35 | 1 | Arneson, | Complete clot lysis (late) | 3.77 [1.39 10.27] | p=0.04 | 0 | 123 | 4 | Arneson,Common,Elsharawy,Schulman, | Normal venous function (late) | 2.09 [0.68 6.45] | p=1.00 | 0 | 66 | 2 | Elsharawy,Schulman, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |