propranolol trial summary

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
All cause death	1.01 [0.78 1.30]	p=1.00	0	2685	21	Balcon ,Barber ,Clausen ,Curtis ,Dotremont ,Gupta ,Gupta ,Hutton ,Kahler ,Ledwich ,Mueller ,Multicentre ,Nigam ,Norris ,Norris ,Norris ,Peter ,Pitt ,Roberts ,Singh ,Sloman ,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Long term beta-blockers: 5 trials - Aronow - Baber - BHAT - Hansteen - Wilcox

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiac event (fatal and non fatal )	0.72 [0.35 1.50]	p=1.00	0	158	1	Aronow ,
reinfarction	0.60 [0.14 2.60]	p=1.00	0	158	1	Aronow ,
Sudden death	no data
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
cardiac death	0.71 [0.37 1.38]	p=1.00	0	158	1	Aronow ,
All cause death	0.73 [0.37 1.45]	p=1.00	0	158	1	Aronow ,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

No demonstrated result

suggested Cardiovascular death by 26% (not demonstrated)

suggested cardiac death by 29% (not demonstrated)

suggested All cause death by 24% (not demonstrated)

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiac event (fatal and non fatal )	0.73 [0.46 1.18]	p=1.00	0	560	1	Hansteen ,
reinfarction	0.86 [0.68 1.09]	p=1.00	0	5117	3	Baber ,BHAT ,Hansteen ,
Sudden death	0.49 [0.23 1.02]	p=1.00	0	560	1	Hansteen ,
cardiovascular events	no data
Cardiovascular death	0.74 [0.59 0.95]	p=0.04	0	3837	1	BHAT ,
myocardial infarction (fatal and non fatal)	1.35 [0.92 1.98]	p=1.00	0	1280	2	Baber ,Hansteen ,
cardiac death	0.71 [0.58 0.87]	p=0.04	0	5117	3	Baber ,BHAT ,Hansteen ,
All cause death	0.76 [0.63 0.93]	p=0.04	0	5117	3	Baber ,BHAT ,Hansteen ,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
reinfarction	no data
cardiac event (fatal and non fatal )	no data
Sudden death	no data
cardiovascular events	no data
Cardiovascular death	0.86 [0.46 1.60]	p=1.00	0	388	1	Wilcox ,
myocardial infarction (fatal and non fatal)	no data
cardiac death	no data
All cause death	0.94 [0.52 1.72]	p=1.00	0	388	1	Wilcox ,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

All type of patient: 1 trials - Berglund

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Heart failure	no data
Diabetes onset	no data
All cause death	1.25 [0.32 4.94]	p=1.00	0	106	1	Berglund,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Uncomplicated hypertension: 1 trials - Berglund

No demonstrated result

Endpoint	TE [95% CI]	p val	I2	n	k	trials
cardiovascular events	no data
Cardiovascular death	no data
myocardial infarction (fatal and non fatal)	no data
stroke (fatal and non fatal)	no data
Coronary event	no data
Heart failure	no data
Diabetes onset	no data
All cause death	1.25 [0.32 4.94]	p=1.00	0	106	1	Berglund,

TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients

Propranolol beta-blockers