Enoxaparin LMWH

Clexane - Lovenox

Acute coronary syndrome

All type of patients:  7 trials  - ESSENCE - TIMI 11 B (short term) - SYNERGY - INTERACT - EVET - TIMI 11 B (long term) - RESCUE

enoxaparin vs tinzaparin

No demonstrated result

suggested death, myocardial infarction, or recurrent at 30 days by 37% (not demonstrated)

enoxaparin vs UFH (on top of aspirin)

No demonstrated result

Minor bleeding by 40% (harmful effect)

Major bleeding by 15% (harmful effect)

suggested death, myocardial infarction, or recurrent at 30 days by 17% (not demonstrated)

suggested recurrent angina by 19% (not demonstrated)

suggested myocardial infarction (fatal and non fatal) by 12% (not demonstrated)

suggested Revascularization by 14% (not demonstrated)

enoxaparin vs unfractionated heparin

No demonstrated result

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Unstable angina:  1 trials  - RESCUE

enoxaparin vs unfractionated heparin

No demonstrated result

Acute myocardial infarction

All type of patients:  6 trials  - ASSENT 3 - HART II - Baird - ENTIRE-TIMI 2 - ASSENT 3 Plus - AMI-SK

Enoxaparin vs placebo

No demonstrated result

suggested reinfarction by 66% (not demonstrated)

suggested reinfarction at 30 days by 68% (not demonstrated)

Enoxaparin vs UFH

No demonstrated result

suggested reinfarction by 39% (not demonstrated)

suggested reinfarction at 30 days by 36% (not demonstrated)

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Patients eligible to receive fibrinolytic therapy:  2 trials  - HART II - Baird

Enoxaparin vs UFH

No demonstrated result

Heart failure

Patients hospitalized for heart failure:  1 trials  - THE-PRINCE (Kleber)

enoxaparin vs UFH

No demonstrated result

Percutaneous coronary intervention

All type of patients:  10 trials  - STEEPLE - Rabah - CRUISE - Galeote - Dudek - Dudek b (enox alone) - Drozd - Dubek b (+abciximal) - STREAM - ATOLL

enoxaparin vs UFH

No demonstrated result

enoxaparin vs unfractionated heparin

No demonstrated result

enoxaparin+abciximab vs UFH

No demonstrated result

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MI patients undergoing primary PCI:  2 trials  - STREAM - ATOLL

enoxaparin vs UFH

No demonstrated result

enoxaparin vs unfractionated heparin

No demonstrated result

Patients undergoing primary PCI:  1 trials  - ATOLL

enoxaparin vs UFH

No demonstrated result

Pulmonary embolism

All type of patients:  2 trials  - PREPIC - Merli sub group

Enoxaparin vs unfractionated heparin

No demonstrated result

Superficial thrombophlebitis

Superficial thrombophlebitis of the leg :  2 trials  - Stenox (enoxaparin 40mg) - STENOX (enoxaparin 1.5mg/hg)

enoxaparin vs placebo

No demonstrated result

Thrombosis prevention

Abdominal surgery:  2 trials  - McLeod (Canadian) - Gonzalez

enoxaparin vs unfractionated heparin

No demonstrated result

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Arthroscopy:  1 trials  - Canata

enoxaparin vs control

No demonstrated result

Elective hip replacement:  7 trials  - Turpie - DES Group - Planes - Levine - Samama - Kalodiki - Warwick

enoxaparin vs Dextran

No demonstrated result

enoxaparin vs no treatment

No demonstrated result

enoxaparin vs placebo

No demonstrated result

enoxaparin vs Unfractionated heparin

No demonstrated result

Elective major knee surgery :  1 trials  - Leclerc

enoxaparin vs placebo

No demonstrated result

General surgery:  10 trials  - Ho [43] - Samama 1 - Samama 2 - Samama 3 - Kaaja - Gazzaniga (ISG) - Nurmohamed - McLeod (Canadian) - Gonzalez - ENOXACAN

enoxaparin vs no treatment

No demonstrated result

suggested Bleeding by 278% (not demonstrated)

enoxaparin vs unfractionated heparin

No demonstrated result

Gynaecological surgery:  1 trials  - Kaaja

enoxaparin vs unfractionated heparin

No demonstrated result

Medical patients:  6 trials  - MEDENOX - Lederle - Bergmann and Neuhart - Lechler - Kleber - LIFENOX

Enoxaparin vs placebo

No demonstrated result

suggested asymptomatic DVT by 61% (not demonstrated)

enoxaparin vs UFH

No demonstrated result

Neurosurgery:  2 trials  - Agnelli - Melon

enoxaparin vs placebo

No demonstrated result

Orthopedic surgery:  11 trials  - Turpie - Leclerc - DES Group - Planes - Levine - Samama - Kalodiki - Warwick - Bergqvist - Planes - Comp

enoxaparin vs Dextran

No demonstrated result

enoxaparin vs no treatment

No demonstrated result

enoxaparin vs placebo

No demonstrated result

enoxaparin vs Unfractionated heparin

No demonstrated result

out of hospital Enoxaparin vs standard prophylaxis

No demonstrated result

suggested Symptomatic deep-vein thrombosis by 69% (not demonstrated)

suggested Symptomatic venous thromboembolism (DVT, PE) by 73% (not demonstrated)

suggested asymptomatic DVT by 42% (not demonstrated)

suggested proximal DVT by 67% (not demonstrated)

Urologic surgery:  1 trials  - LeGagneux

enoxaparin vs placebo

No demonstrated result

Venous thrombosis

All type of patients:  9 trials  - Simonneau et al - Merli - Merli (once daily vs UFH) - Pini - Gonzalez-Fajardo - Veiga - Meyer - Deitcher - González-Fajardo

Enoxaparin vs acenocoumarol

No demonstrated result

Enoxaparin vs coumarin

No demonstrated result

suggested VTE during active anticoagulant treatment by 97% (not demonstrated)

Enoxaparin vs unfractionated heparin

No demonstrated result

Enoxaparin vs warfarin

No demonstrated result

once daily enoxaparin vs twice daily enoxaparin

No demonstrated result

once daily enoxaparin vs UFH

No demonstrated result

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Patients with cancer:  3 trials  - Cesarone - Deitcher - Meyer

extended enoxaparin vs standard treatment

No demonstrated result