encorafenib plus binimetinib vs vemurafenib | No demonstrated result suggested progression or death (progression free survival PFS) by 46% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | aaa | no data | recurrence free survival | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | 0.54 [0.41 0.71] | p=0.04 | 0 | 383 | 1 | COLUMBUS, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |