durvalumab vs placebo | progression or death (progression free survival PFS) by 48% (fully demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | 0.52 [0.42 0.65] | p=0.04 | 0 | 709 | 1 | PACIFIC, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
durvalumab vs Standard of Care | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
durvalumab + osimertinib vs osimertinib | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
durvalumab + tremelimumab vs platinum-based CT | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
durvalumab + tremelimumab vs Standard of Care | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
---|
objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
durvalumab +tremelimumab vs Standard of Care | No demonstrated result | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | Grade 3–5 drug-related AEs | no data | death (overall survival) | no data | progression or death (progression free survival PFS) | no data | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |