Durvalumab immune checkpoint inhibition

Imfinzi - durvalumab

Head and neck cancer

All type of patients:  1 trials  - Hawk

durvalumab vs standard treatment

No demonstrated result

Lung cancer (metastatic)

All type of patients:  8 trials  - PACIFIC - ARCTIC PD-L1 positive - MYSTIC (combination) - NCT02273375 - CAURAL - NEPTUNE - MYSTIC (monotherapy) - ARCTIC PD-L1 negative

durvalumab vs placebo

progression or death (progression free survival PFS) by 48% (fully demonstrated)

durvalumab vs Standard of Care

No demonstrated result

durvalumab + osimertinib vs osimertinib

No demonstrated result

durvalumab + tremelimumab vs platinum-based CT

No demonstrated result

durvalumab + tremelimumab vs Standard of Care

No demonstrated result

durvalumab +tremelimumab vs Standard of Care

No demonstrated result

See more clinical conditions

First line:  3 trials  - MYSTIC (combination) - NEPTUNE - MYSTIC (monotherapy)

durvalumab vs Standard of Care

No demonstrated result

durvalumab + tremelimumab vs platinum-based CT

No demonstrated result

durvalumab +tremelimumab vs Standard of Care

No demonstrated result

Second line :  3 trials  - ARCTIC PD-L1 positive - CAURAL - ARCTIC PD-L1 negative

durvalumab vs Standard of Care

No demonstrated result

durvalumab + osimertinib vs osimertinib

No demonstrated result

durvalumab + tremelimumab vs Standard of Care

No demonstrated result

Urothelial carcinoma (advanced)

All type of patients:  2 trials  - DANUBE - durvalumab phase 1/2

durvalumab vs nil

No demonstrated result

durvalumab + tremelimumab vs chemotherapy

No demonstrated result