Erlotinib EGFR inhibitors

OSI-774 - CP-358774 - CP 358774 - Tarceva

Lung cancer (metastatic)

All type of patients:  11 trials  - OPTIMAL - EUTRAC - TITAN - TRIBUTE (Herbst) - Gatzemeier - Mok - SATURN (Cappuzzo) - Boutsikou - Lee - Stinchcombe - FASTACT-2 (Wu)

erlotinib vs Platinum-based CT

No demonstrated result

suggested progression or death (progression free survival PFS) by 73% (not demonstrated)

erlotinib + Platinum-based CT vs Platinum-based CT

No demonstrated result

suggested objective response (ORR) by 30% (not demonstrated)

suggested death (overall survival) by 11% (not demonstrated)

suggested progression or death (progression free survival PFS) by 22% (not demonstrated)