erlotinib vs Platinum-based CT | No demonstrated result suggested progression or death (progression free survival PFS) by 73% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | no data | death (overall survival) | 0.96 [0.78 1.19] | p=1.00 | 0 | -18 | 1 | TITAN, | progression or death (progression free survival PFS) | 0.27 [0.20 0.36] | p=0.04 | 0 | -36 | 2 | OPTIMAL ,EUTRAC, | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
erlotinib + Platinum-based CT vs Platinum-based CT | No demonstrated result suggested objective response (ORR) by 30% (not demonstrated) suggested death (overall survival) by 11% (not demonstrated) suggested progression or death (progression free survival PFS) by 22% (not demonstrated) | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
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objective response (ORR) | 1.30 [1.14 1.47] | p=0.04 | 0 | -108 | 6 | TRIBUTE (Herbst), Gatzemeier , Mok ,Lee ,Stinchcombe,FASTACT-2 (Wu) , | death (overall survival) | 0.89 [0.81 0.97] | p=0.04 | 0 | -126 | 7 | TRIBUTE (Herbst), Mok ,SATURN (Cappuzzo), Boutsikou,Lee ,Stinchcombe,FASTACT-2 (Wu) , | progression or death (progression free survival PFS) | 0.78 [0.72 0.84] | p=0.04 | 0 | -90 | 5 | Gatzemeier , Mok ,Lee ,Stinchcombe,FASTACT-2 (Wu) , | TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |