Eplerenone aldosterone blockade

Inspra - eplerenon

Heart failure

All type of patients:  4 trials  - EPHESUS - REMODEL - Weir - EMPHASIS-HF

eplerenone vs placebo

No demonstrated result

suggested death from cardiovascular causes or hospitalization for cardiovascular causes by 11% (not demonstrated)

suggested serious hyperkalemia by 63% (not demonstrated)

suggested Sudden death by 20% (not demonstrated)

suggested Death from any cause or hospitalization for any reason by 18% (not demonstrated)

suggested Death from any cause or hospitalization for heart failure by 28% (not demonstrated)

suggested Cardiovascular death by 17% (not demonstrated)

suggested hospitalisation for heart failure by 35% (not demonstrated)

suggested All cause death by 15% (not demonstrated)

suggested Hospitalization for any reason by 16% (not demonstrated)

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Left Ventricular Dysfunction after Myocardial Infarction:  2 trials  - EPHESUS - Weir

eplerenone vs placebo

No demonstrated result

suggested death from cardiovascular causes or hospitalization for cardiovascular causes by 11% (not demonstrated)

suggested serious hyperkalemia by 43% (not demonstrated)

suggested Sudden death by 20% (not demonstrated)

suggested Cardiovascular death by 16% (not demonstrated)

suggested All cause death by 14% (not demonstrated)




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