| vitamin E vs control | No demonstrated result | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| cardiovascular events | 0.99 [0.88 1.11] | p=1.00 | 0 | 15819 | 2 | GISSI,PPP, | | Cardiovascular death | 0.94 [0.80 1.09] | p=1.00 | 0 | 15819 | 2 | GISSI,PPP, | | stroke (fatal and non fatal) | 0.93 [0.71 1.22] | p=1.00 | 0 | 15829 | 2 | GISSI,PPP, | | ischemic stroke | 1.13 [0.59 2.14] | p=1.00 | 0 | 4495 | 1 | PPP, | | Coronary event | 0.89 [0.50 1.59] | p=1.00 | 0 | 4495 | 1 | PPP, | | Coronary death | no data | | Non fatal MI | 1.11 [0.92 1.33] | p=1.00 | 0 | 15819 | 2 | GISSI,PPP, | | All cause death | 0.94 [0.83 1.06] | p=1.00 | 0 | 15829 | 2 | GISSI,PPP, | | Non fatal stroke | 0.95 [0.73 1.26] | p=1.00 | 0 | 15819 | 2 | GISSI,PPP, | | Haemmorhagic stroke | 5.07 [0.24 105.75] | p=1.00 | 0 | 4495 | 1 | PPP, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
| vitamin E vs placebo | No demonstrated result suggested Haemmorhagic stroke by 22% (not demonstrated) | | Endpoint | TE [95% CI] | p val | I2 | n | k | trials |
|---|
| cardiovascular events | 0.97 [0.92 1.03] | p=1.00 | 0 | 93072 | 6 | ATBC vitamin E,CHAOS,HOPE,Linxian,WACS vitamin E,PHS II vitamin E, | | Cardiovascular death | 0.99 [0.92 1.05] | p=1.00 | 0 | 93072 | 6 | ATBC vitamin E,CHAOS,HOPE,Linxian,WACS vitamin E,PHS II vitamin E, | | stroke (fatal and non fatal) | 0.98 [0.91 1.06] | p=1.00 | 0 | 101362 | 5 | ATBC vitamin E,HOPE,WACS vitamin E,PHS II vitamin E,WHS vitamin E, | | ischemic stroke | 0.94 [0.86 1.02] | p=1.00 | 0 | 100748 | 5 | ATBC vitamin E,HOPE,WACS vitamin E,PHS II vitamin E,WHS vitamin E, | | Coronary event | 0.92 [0.72 1.17] | p=1.00 | 0 | 8171 | 1 | WACS vitamin E, | | Coronary death | no data | | Non fatal MI | 0.96 [0.85 1.07] | p=1.00 | 0 | 19714 | 3 | CHAOS,HOPE,WACS vitamin E, | | All cause death | 1.03 [0.96 1.11] | p=1.00 | 0 | 30091 | 5 | CHAOS,AREDS,WACS vitamin E,PHS II vitamin E,ASAP, | | Non fatal stroke | 1.01 [0.86 1.18] | p=1.00 | 0 | 17712 | 2 | HOPE,WACS vitamin E, | | Haemmorhagic stroke | 1.22 [1.00 1.48] | p=0.04 | 0 | 100748 | 5 | ATBC vitamin E,HOPE,WACS vitamin E,PHS II vitamin E,WHS vitamin E, |
TE: treatment effect; CI: confidence interval; k: nulmber of trials; n: total number of patients |
