beta-blockers
Trials Results

Acebutolol - Alprenolol - Atenolol - Betaxolol - Bisoprolol - Bucindolol - Carvedilol - Labetalol - Metoprolol - Metroprolol - Nebivolol - Oxprenolol - Pindolol - Practolol - Propranolol - Sotalol - Timolol - Various beta blockers

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute myocardial infarction

acebutolol
Azancot, 1982AcebutololplaceboNegative
APSI, 1990Acebutolol placeboSuggesting
alprenolol
Wilhelmsson , 1974Alprenolol placeboNegative
Andersen , 1979Alprenolol placeboNegative
atenolol
Yusuf , 1980AtenololplaceboNegative
ISIS1 Collaborative Group , 1986AtenololplaceboNegative
Van de Werf , 1993AtenololplaceboNegative
betaxolol
Yang , 1987BetaxololplaceboNegative
carvedilol
Basu , 1997Carvedilol placeboSuggesting
labetalol
Heber , 1987LabetalolplaceboNegative
metoprolol
Waagstein , 1975PractololormetoprololplaceboNegative
Hjalmarson , 1981MetoprololplaceboSuggesting
Von Essen , 1982placeboNegative
Manger Cats , 1983Metoprolol placeboNegative
Rehnqvist , 1983Metoprolol placeboSuggesting
MIAMI Trial Research Group , 1985placeboNegative
Salathia , 1985MetoprololplaceboSuggesting
LIT Research Group , 1987Metoprolol placeboNegative
TIMI IIB, 1989placeboNegative
oxprenolol
Fuccella , 1968OxprenololplaceboNegative
Lombardo , 1979OxprenololplaceboNegative
Wilcox , 1980OxprenololplaceboNegative
CPRG , 1981OxprenololplaceboNegative
Taylor , 1982Oxprenolol placeboNegative
EIS , 1984Oxprenolol placeboNegative
Schwartz (high risk and low risk) , 1992Oxprenolol placeboSuggesting
pindolol
Australian and Swedish study, 1983Pindolol placeboNegative
Owensby , 1984PindololplaceboNegative
practolol
Multicentre international , 1975Practolol placeboSuggesting
Evemy , 1978PractololplaceboNegative
Thompson , 1979PractololplaceboNegative
Johansson , 1980PractololplaceboNegative
Macleod , 1980PractololplaceboNegative
Snow , 1980PractololplaceboNegative
propranolol
Balcon , 1966PropranololplaceboNegative
Clausen , 1966PropranololplaceboNegative
Multicentre , 1966PropranololplaceboNegative
Sloman , 1967PropranololplaceboNegative
Dotremont , 1968PropranololplaceboNegative
Kahler , 1968PropranololplaceboNegative
Ledwich , 1968PropranololplaceboNegative
Norris , 1968PropranololplaceboNegative
Barber , 1976PropranololplaceboNegative
Pitt , 1976PropranololplaceboNegative
Norris , 1978PropranololplaceboNegative
Peter , 1978PropranololplaceboNegative
Hutton , 1979PropranololplaceboNegative
Mueller , 1980PropranololplaceboNegative
Baber , 1980Propranolol placeboNegative
Wilcox , 1980Propranolol or atenolol placeboSuggesting
Gupta , 1982PropranololplaceboNegative
BHAT , 1982Propranolol placeboSuggesting NCT00000492
Hansteen , 1982Propranolol placeboSuggesting
Nigam , 1983PropranololplaceboNegative
Gupta , 1984PropranololplaceboNegative
Norris , 1984PropranololplaceboNegative
Roberts , 1984PropranololplaceboNegative
Singh , 1985PropranololplaceboNegative
Curtis , 1991PropranololplaceboNegative
Aronow , 1997Propranolol controlSuggesting
sotalol
Lloyd , 1988SotalolplaceboNegative
timolol
Tonkin , 1981TimololplaceboNegative
Norwegian Multicentre Study Group , 1981Timolol placeboSuggesting
UKCSG , 1983TimololplaceboNegative
Campbell , 1984TimololplaceboNegative
Federman , 1984TimololplaceboNegative
ICSG , 1984TimololplaceboNegative
Ranganathan , 1988TimololplaceboNegative
xamoterol
McMurray , 1991XamoterolplaceboNegative

heart failure

bisoprolol
CIBIS, 1994bisoprololplaceboSuggesting
CIBIS II, 1999bisoprololplaceboSuggesting
CIBIS II (elderly subgroup), 1999BisoprololplaceboSuggesting
bucindolol
Pollock, 1990Bucindololplacebo -
Woodley, 1991Bucindololplacebo -
Bristow, 1994Bucindololplacebo -
MERIT-HF (elderly subgroup), 1999BucindololplaceboSuggesting
BEST, 2001bucindololplaceboSuggestingNCT00000560
carvedilol
Metra, 1994carvedilolplacebo -
Olsen, 1995carvedilolplacebo -
Krum, 1995carvedilolplacebo -
Bristow (MOCHA), 1996carvedilolplacebo -
Parker, 1996carvedilolplaceboNegative
Colucci, 1996carvedilolplacebo -
Carvedilol U.S. Trials (elderly subgroup), 1996CarvedilolplaceboSuggesting
ANZ-HeFT, 1997carvedilolplaceboNegative
Cohn, 1997carvedilolplacebo -
CAPRICORN, 2001carvedilolplaceboSuggesting
COPERNICUS (elderly subgroup), 2001CarvedilolplaceboSuggesting
COPERNICUS, 2002carvedilolplaceboSuggesting
COMET, 2003carvedilolmetoprololSuggesting
CARMEN (carvedilol alone), 2004carvedilolenalaprilNegative
CARMEN (carvedilol+enalapril), 2004 ongoing carvedilol+enalaprilenalapril -
metoprolol
Engelmeier, 1985metoprololplacebo -
MDC (Waagstein), 1993metoprololplaceboNegative
Fisher, 1994metoprololplacebo -
Eichhorn, 1994metoprololplacebo -
MERIT-HF, 1999metoprololplaceboSuggesting
RESOLVD, 2000metoprololplacebo -
BEST (elderly subgroup), 2001MetoprololplaceboNegative
nebivolol
Lechat, 1991Nebivololplacebo -
Wisenbaugh, 1993NebivololplaceboNegative
SENIORS, 2005nebivololplacebo -



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