inhibition of the renin-angiotensin system (ACEI or ARB)

TrialStudied treatmentControl treatmentpatientsROBResultNCT

heart failure

candesartan
CHARM preserved, 2003candesartanplacebo Low risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008ibesartanplacebo Low risk of bias NegativeNCT00095238
perindopril
PEP CHF, 2006perindoprilplacebo Low risk of bias Negative

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004enalaprilplaceboNegative
perindopril
EUROPA, 2003perindoprilplaceboSuggesting
quinapril
QUIET, 2001quinaprilplaceboNegative
ramipril
HOPE, 2000ramiprilplaceboSuggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNegative NCT00153101
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanSuggesting NCT00153101
telmisartan
ONTARGET (telmisartan alone), 2008telmisartanramipril Low risk of bias Suggesting NCT00153101
TRANSCEND, 2008telmisartanplacebo Low risk of bias SuggestingNCT00153101
trandolapril
PEACE, 2004trandolaprilplaceboSuggestingNCT00000558