anti hypertensive agents trial summary

Trial	Studied treatment	Control treatment	ROB	Result	NCT
diabetes type 2
amlodipine
FACET, 1997	amlodipine	fosinopril	Risk of bias	Suggesting
IDNT (amlodipine vs PBO), 2001	amlodipine	placebo	Low risk of bias	Negative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002	amlodipine	chlorthalidone	Exploratory	Negative
candesartan
SCOPE (diabetic subgroup), 2003	candesartan	control	Exploratory	Negative
captopril
UKPDS 39, 1998	captopril	atenolol	Exploratory	Negative
UKPDS 38, 1998	captopril or atenolol	control	Exploratory	Suggesting
CAPP (diabetic subgroup), 1999	captopril	diuretic and/or beta-blockers	Exploratory	Suggesting
chlorthalidone
SHEP (diabetic subgroup), 1996	chlorthalidone	placebo	Exploratory	Suggesting
intensive blood pressure lowering strategies
ABCD target (H) , 2000	more intensive blood pressure lowering strategie	less intensive blood pressure lowering strategie		Suggesting
ABCD target (N) , 2002	more intensive blood pressure lowering strategie	less intensive blood pressure lowering strategie		Suggesting
irbesartan
IPDM (150mg), 2001	irbesartan	placebo	Exploratory	Suggesting
IDNT (irbesartan vs pbo), 2001	irbesartan	placebo	Low risk of bias	Suggesting
IDNT (irbesartan vs amlodipine), 2001	irbesartan	amlodipine	Low risk of bias	Suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002	lisinopril	chlorthalidone	Exploratory	Negative
losartan
RENAAL, 2001	losartan	placebo	Low risk of bias	Suggesting
LIFE (diabetic subgroup), 2002	losartan	atenolol	Exploratory	Suggesting
metoprolol
MERIT-HF, 2005	metoprolol	placebo		Negative
nidrendipine
Syst-Eur (diabetic subgroup), 1999	nitrendipine	placebo	Exploratory	Suggesting
nifedipine
INSIGHT (diabetic subgroup), 2000	nifedipine	coamilozide	Exploratory	Negative
nisoldipine
ABCD (hypertension), 1998	nisoldipine	enalapril	Exploratory	Suggesting
olmesartan
ORIENT	olmesartan	placebo		Negative	NCT00141453
ROADMAP, 2010	olmesartan	placebo	Low risk of bias	Suggesting	NCT00185159
ramipril
DIABHYCAR, 2004	ramipril	placebo	Low risk of bias	Negative
DREAM, 2008	ramipril	placebo		Negative
hypertension
aliskiren
AVOID, 2008	aliskiren	placebo	Exploratory	Negative	NCT00097955
Andersen, 2008	aliskiren	ramipril	Exploratory	-
Schmieder (vs HCTZ), 2009	aliskiren	hydrochlorothiazide	Exploratory	Negative
ALLAY, 2009	aliskiren	losartan	Exploratory	Negative	NCT00219141
ACCELERATE, 2011	aliskiren	amlodipine		-	NCT00797862
amlodipine
FACET, 1997	amlodipine	fosinopril	Risk of bias	Suggesting
IDNT (amlodipine vs PBO), 2001	amlodipine	placebo	Low risk of bias	Negative
IDNT (amlodipine vs pbo), 2001	amlodipine	placebo		Negative
ALLHAT (CCB vs ACEI), 2002	amlodipine	lisinopril		Suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002	amlodipine	chlorthalidone	Exploratory	Negative
AASK (amlodipine vs metoprolol), 2002	amlodipine	metoprolol		Negative
ALLHAT (CCB vs diu), 2002	amlodipine	chlorthalidone		Negative
ASCOT-BPLA, 2005	amlodipine	atenolol	Risk of bias	Suggesting
ACCOMPLISH, 2008	amlodipine plus benazepril	hydrochlorothiazide plus benazepril	Low risk of bias	Suggesting	NCT00170950
Tepel et al, 2008	amlodipine	placebo		Negative	NCT00124969
atenolol
MRC I (vs placebo), 1985	atenolol	placebo		Suggesting
MRC I (vs diuretics), 1985	atenolol	bendroflumethiazide	Risk of bias	Negative
Coope, 1986	atenolol	control		Suggesting
Coope (subgroup ), 1986	atenolol	control		Negative
MRC old (vs placebo), 1992	atenolol	placebo		Negative
MRC old (vs diuretics), 1992	atenolol	hydrochlorothiazide+amiloride		Negative
Dutch TIA, 1993	atenolol	placebo		Suggesting
TEST, 1995	atenolol	placebo		Negative
candesartan
HSCS, 1974	deserpidine +methylclothiazide	placebo		Negative
SCOPE, 2003	candesartan	placebo	Low risk of bias	Negative
ALPINE, 2003	candesartan	hydrochlorothiazide	Low risk of bias	Suggesting
E-COST, 2005	candesartan	conventional treatment	Risk of bias	Suggesting
E-COST-R, 2005	candesartan	conventional treatment	Risk of bias	Negative
Takahashi, 2006	candesartan	control	Exploratory	Negative
Takahashi et al, 2006	candesartan	usual care		Suggesting
TROPHY, 2006	candesartan	placebo	Exploratory	Suggesting	NCT00227318
CASE-J, 2008	candesartan	amlodipine	Risk of bias	Suggesting
Suzuki et al, 2008	candesartan	usual care		Suggesting
HIJ-CREATE, 2009	candesartan	conventional treatment	Risk of bias	Suggesting
captopril
UKPDS 39, 1998	captopril	atenolol	Exploratory	Negative
UKPDS 38, 1998	captopril or atenolol	control	Exploratory	Suggesting
UKPDS-HDS, 1998	captopril	diuretic or beta-blocker		Negative
CAPP (diabetic subgroup), 1999	captopril	diuretic and/or beta-blockers	Exploratory	Suggesting
CAPPP, 1999	captopril	diuretic or beta-blocker	Risk of bias	Negative
carvedilol
Cice et al, 2003	carvedilol	placebo		Suggesting
Nakao et al, 2007	carvedilol	placebo		-
chlorthalidone
VA-NHLBI, 1977	chlorthalidone	placebo		Negative
SHEP-pilot, 1989	chlorthalidone	placebo		Negative
SHEP-P (subgroup ), 1989	chlorthalidone	placebo		Suggesting
SHEP, 1991	chlorthalidone	placebo		Suggesting	NCT00000514
SHEP (subgroup ), 1991	chlorthalidone	placebo		Suggesting
SHEP (diabetic subgroup), 1996	chlorthalidone	placebo	Exploratory	Suggesting
diltiazem
NORDIL, 2000	diltiazem	diuretic or beta-blocker		Suggesting
enalapril
ABCD (H), 1998	enalapril	nisoldipine		Suggesting
ANBP2, 2003	enalapril	diuretics	Risk of bias	Negative
fosinopril
Zannad et al, 2006	fosinopril	placebo		Negative
hydrochlorothiazide
Kuramoto, 1981	hydrochlorothiazide + triamterene	placebo		Negative
EWPHE, 1985	hydrochlorothiazide + triamterene	placebo		Suggesting
EWPHE (subgroup ), 1985	hydrochlorothiazide	placebo		Negative
indapamide
HAPPY, 1987				Negative
PATS, 1995	indapamide	placebo		Negative
HYVET pilot, 2003				-
HYVET, 2008	indapamide	placebo		Suggesting	NCT00122811
intensive blood pressure lowering strategies
ABCD target (H) , 2000	more intensive blood pressure lowering strategie	less intensive blood pressure lowering strategie		Suggesting
ABCD target (N) , 2002	more intensive blood pressure lowering strategie	less intensive blood pressure lowering strategie		Suggesting
irbesartan
IPDM (150mg), 2001	irbesartan	placebo	Exploratory	Suggesting
IDNT (irbesartan vs pbo), 2001	irbesartan	placebo	Low risk of bias	Suggesting
IDNT (irbesartan vs amlodipine), 2001	irbesartan	amlodipine	Low risk of bias	Suggesting
IRMA 2, 2001	irbesartan	placebo	Low risk of bias	Negative
IDNT (irbesartan vs pbo), 2001	irbesartan	placebo	Low risk of bias	Negative
isradipine
MIDAS, 1996	isradipine	hydrochlorothiazide		Negative
lacidipine
ELSA, 2002	lacidipine	atenolol		-
SHELL, 2003	lacidipine	chlorthalidone		-
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002	lisinopril	chlorthalidone	Exploratory	Negative
ALLHAT (ACEI vs chlorthalidone), 2002	lisinopril	diuretics	Low risk of bias	Negative
ALLHAT (ACEI vs amlodipine), 2002	lisinopril	amlodipine		Suggesting
losartan
RENAAL, 2001	losartan	placebo	Low risk of bias	Suggesting
RENAAL, 2001	losartan	placebo	Low risk of bias	-
LIFE (diabetic subgroup), 2002	losartan	atenolol	Exploratory	Suggesting
LIFE, 2002	losartan	atenolol	Low risk of bias	Suggesting
nicardipine
NICS-EH, 1999	nicardipine	trichlormethiazide		Negative
nidrendipine
SYST-EUR, 1997	nitrendipine	placebo		Suggesting
Syst-Eur (subgroup ), 1997	nidrendipine	placebo		Negative
Syst-Eur (diabetic subgroup), 1999	nitrendipine	placebo	Exploratory	Suggesting
nifedipine
Castel, 1994	nifedipine	atenolol+chlorthalidone		Negative
INSIGHT (diabetic subgroup), 2000	nifedipine	coamilozide	Exploratory	Negative
INSIGHT, 2000	nifedipine	hydrochlorothiazide+amiloride		Suggesting
nisoldipine
ABCD (hypertension), 1998	nisoldipine	enalapril	Exploratory	Suggesting
oxprenolol
IPPPSH, 1985	oxprenolol	placebo		Negative
propranolol
Berglund, 1986	propranolol	bendroflumethiazide		Negative
ramipril
AASK (ramipril vs metoprolol), 2002	ramipril	metoprolol		Negative
AASK (ramipril vs amlodipine), 2002	ramipril	amlodipine		Negative
Li et al, 2003	ramipril	usual care		Negative
telmisartan
Cice et al, 2006	telmisartan	placebo		Suggesting
PROPHESS, 2008	telmisartan	placebo	Low risk of bias	Negative	NCT00153062
thiazid diuretic
Carter, 1970	thiazide diuretics	control		Suggesting
ANBPS (Australian ), 1980	thiazide diuretics	control		Negative
Oslo (Hegeland), 1980	thiazide diuretics	control		Negative
MCR 35-64 (diuretics vs pbo), 1985	thiazide diuretics	placebo		Suggesting
various ACEI
STOP-2 (ACEI vs felodipine or isradipine), 1999	various ACEI	calcium-channel blocker		Suggesting
STOP 2 (ACEI vs diurectic or beta-blocker), 1999	various ACEI	diuretic or beta-blocker		Suggesting
JMIC-B, 2002	various ACEI	nifedipine		-
various beta blockers
HAPPHY, 1988	various beta-blockers	diuretics		Negative
STOP, 1991	various beta-blockers	placebo		Suggesting
Yurenev, 1992	various beta-blockers	diuretics		Negative
various diuretics
VA-I, 1967	High-dose diuretics	placebo		Suggesting
VA II, 1970	High-dose diuretics	placebo		Suggesting
Barraclough, 1973	High-dose diuretics	placebo		Negative
HDFP, 1979	High-dose diuretics	control		Suggesting	NCT00000485
MRC (diu vs BB), 1985	High-dose diuretics	beta-blockers		-
verapamil
VHAS, 1998	verapamil	chlorthalidone		Negative
CONVINCE, 2003	verapamil	diuretic or beta-blocker		Negative
INVEST (Pepine), 2003	verapamil	atenolol		Negative	NCT00133692
post stroke
telmisartan
PROFESS, 2008	telmisartan	placebo		-

anti hypertensive agents Trials Results

Group by...

diabetes type 2

amlodipine

candesartan

captopril

chlorthalidone

intensive blood pressure lowering strategies

irbesartan

lisinopril

losartan

metoprolol

nidrendipine

nifedipine

nisoldipine

olmesartan

ramipril

hypertension

aliskiren

amlodipine

atenolol

candesartan

captopril

carvedilol

chlorthalidone

diltiazem

enalapril

fosinopril

hydrochlorothiazide

indapamide

intensive blood pressure lowering strategies

irbesartan

isradipine

lacidipine

lisinopril

losartan

nicardipine

nidrendipine

nifedipine

nisoldipine

oxprenolol

propranolol

ramipril

telmisartan

thiazid diuretic

various ACEI

various beta blockers

various diuretics

verapamil

post stroke

telmisartan

anti hypertensive agents
Trials Results