endothelin receptor antagonist
Trials Results

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute heart failure

nesiritide
NSGET (efficacy trial), 2000nesiritideplacebo Low risk of bias Negative
NSGET (comparative trial), 2000nesiritidecontrol Low risk of bias -
VMAC (24h), 2002nesiritidenitroglycerin Risk of bias NegativeNCT00083772
VMAC (intravenous neseritide), 2002nesiritideplacebo Low risk of bias - NCT00083772
PRECEDENT, 2002nesiritidedobutamine Exploratory - NCT00270400
PROACTION, 2003nesiritideplacebo Low risk of bias Negative
FUSION 1, 2004nesiritidestandard care Low risk of bias - NCT00270361
BNP-CARDS, 2007nesiritideplacebo Exploratory - NCT00186329
FUSION 2, 2008nesiritideplacebo Low risk of bias - NCT00091520
ASCEND-HF, 2011nesiritideplacebo Low risk of bias Negative NCT00475852



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