HDL increasing drugs
Trials Results

Torcetrapib

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

cardiovascular prevention

anacetrapib
DEFINE, 2010anacetrapibplacebo Exploratory NegativeNCT00685776
REALIZE, 2015anacetrapibplaceboNegativeNCT01524289
bezafibrate
BECAIT, 1996bezafibrateplacebosecondary prevention Exploratory Suggesting
SENDCAP, 1998bezafibrateplacebo Exploratory Suggesting
BIP, 2000bezafibrateplacebosecondary prevention Low risk of bias Negative
LEADER, 2002bezafibrateplacebo Low risk of bias Negative
clofibrate
Harrold, 1969clofibrateplacebo Low risk of bias -
Scottish, 1971clofibrateplacebo Low risk of bias Negative
Newcastle, 1971clofibrateplacebo Low risk of bias Suggesting
Begg, 1971clofibrateplacebosecondary prevention Exploratory Negative
Acheson, 1972clofibrateplacebosecondary prevention Exploratory -
VA Neurology Section, 1974clofibrateplacebo Low risk of bias -
Cullen, 1974clofibrateplacebo Low risk of bias -
CDP Clofibrate, 1975clofibrateplacebo Low risk of bias Suggesting
WHO clofibrate, 1978clofibrateplacebo Low risk of bias Suggesting
Hanefeld, 1991clofibrateplacebo Low risk of bias Negative
etofibrate
Emmerich, 2009etofibrateplacebodiabetic Exploratory -
fenofibrate
DAIS, 2001fenofibrateplacebodiabetic Exploratory Negative
FIELD, 2005fenofibrateplacebodiabetic Exploratory Suggesting ISRCTN64783481
ACCORD lipid, 2010fenofibrateplacebo (on top simvastatine)diabetic patients Low risk of bias NegativeNCT00000620
gemfibrozil
Helsinki (HHS), 1987gemfibrozilplacebo Low risk of bias Suggesting
HHS (Frick)(secondary prev subgroup), 1993gemfibrozilplacebo Exploratory Negative
LOCAT, 1997gemfibrozilplacebo Exploratory Negative
VA-HIT, 1999gemfibrozilplacebo Low risk of bias SuggestingNCT00283335
niacin
HPS 2-Thriveniacinplacebo (on top statin) Low risk of bias NegativeNCT00461630
VA drugs, 1968niacincontrol Low risk of bias Negative
CDP niacin, 1975niacinplacebo Low risk of bias Suggesting
HATS, 2001niacinplacebo (on top statin) Risk of bias Negative
Oxford Niaspan Study, 2009niacinplacebo (on top statin) Exploratory - NCT00232531
ARBITER 2, 2009niacinplacebo (on top statin) Exploratory Negative
ARBITER 6-HALTS (niacin vs ezetimibe), 2009niacinezetimibe Exploratory Suggesting NCT00397657
AIM-HIGH, 2011niacinplacebo (on top statin) Low risk of bias NegativeNCT00120289
torcetrapib
RADIANCE 1, 2007torcetrapibplacebo Exploratory NegativeNCT00136981
ILLUMINATE, 2007torcetrapibplaceboNegative NCT00134264
RADIANCE 2, 2007torcetrapibplacebo Exploratory -
ILLUSTRATE, 2007torcetrapibplacebo Exploratory NegativeNCT00134173



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