insulin secretagogues
Trials Results

Glimeripide - Linagliptin - Mitiglinide - Repaglinide

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

diabetes type 2

alogliptin
DeFronzo , 2008alogliptin - NCT00286455
Nauck, 2009alogliptinplacebo (add on MET) Exploratory Negative NCT00286442
Rosenstock, 2009alogliptin - NCT00286429
Pratley, 2009alogliptin - NCT00286494
Pratley, 2009alogliptin - NCT00286468
Rosenstock, 2010alogliptin - NCT00395512
Seino, 2011alogliptin - NCT01263509
EXAMINE, 2011alogliptinplaceboNegativeNCT00968708
Seino, 2011alogliptin -
Bosi , 2011alogliptin - NCT00432276
Kaku, 2011alogliptin -
gliclazide
Matthews, 2005gliclazidepioglitazone (add on MET) -
Ristic, 2006gliclazidenateglinide (add on MET) -
Khanolkar, 2008gliclaziderosiglitazone (add on MET) -
glimepiride
Charpentier, 2001glimepiride monotherapymetformin -
glimeripide
Protocol 311glimepirideglibenclamide -
Study 202glimepirideplacebo -
Charpentier (301F)glimepiridegliclazide -
Kaneko, 1993glimepirideplacebo -
Riddle, 1994glimepirideplacebo (add on insulin) -
Draeger, 1996glimepirideglibenclamide Low risk of bias -
Dills, 1996glimepirideglyburide Exploratory -
Study 201 (Goldberg), 1996glimepirideplacebo Exploratory -
Rosenstock, 1996glimepirideplacebo -
Clark (301), 1997glimepirideglipizide -
Sonnenberg, 1997glimepiride odglimepiride bid -
Schade, 1998glimepirideplacebo -
Charpentier, 2001glimepirideplacebo (add on MET)Negative
Luis Bautista, 2003glimepirideplacebo -
Inukai, 2005glimepiridegliclazide or glibenclamide -
LEAD-2 (Nauck) Sulf vs pbo, 2009glimepirideplacebo (add on MET) - NCT00318461
glipizide
Goldsteinglipizidecontrol (add on MET) -
Rosenstock, 1993glipizideglyburide -
Birkeland, 1994glipizideglyburide -
Birkeland, 1994glipizideglyburide -
Simonson, 1997glipizideplacebo -
Testa, 1998glipizideplacebo -
Feinglos, 2005glipizide GITSplacebo (add on MET) -
Nauck, 2007glipizidesitagliptin (add on MET) -
glyburide
Hermann, 1991glibenclamidec (add on MET) -
Vray, 1995glyburideplacebo -
DeFronzo, 1995glyburidec (add on MET) -
Erle, 1999glyburidec (add on MET) -
Garber, 2002glyburideplacebo -
Marre (ass), 2002glibenclamidecontrol (add on MET) -
Blonde, 2002glyburidecontrol (add on MET) -
Tosi, 2003glibenclamidecontrol (add on MET) -
Garber, 2003glyburidecontrol (add on MET) -
Garber, 2006glibenclamiderosiglitazone (add on MET) -
linagliptin
Taskinenlinagliptinplacebo (add on MET) - NCT00601250
OwenslinagliptinMetformin + sulfonylurea - NCT00602472
Del Pratolinagliptinplacebo - NCT00621140
Lewin, 2010linagliptinplacebo (add on SU) - NCT00819091
Forst, 2010linagliptin - NCT00309608
Gomis, 2011linagliptinplacebo (add on pioglitazone) - NCT00641043
CAROLINA, 2012linagliptinglimepiride Exploratory SuggestingNCT01243424
Gallwitz, 2012linagliptinglimepiride (add on MET) - NCT00622284
linagliptin 1218.61 ongoing linagliptinplacebo (add on MET+TZD) - NCT00996658
linagliptin 1218.65 ongoing linagliptinplacebo (add on MET) - NCT01215097
linagliptin 1218.62 ongoing linagliptin low doselinagliptin - NCT01012037
linagliptine 1218.50 ongoing linagliptinplacebo - NCT00740051
linagliptin1218.5 ongoing linagliptinplacebo - NCT00328172
linagliptin 1218.46 ongoing linagliptinplacebo - NCT00798161
mitiglinide
Gaomitiglinidenateglinide - NCT00461617
Kumashiro, 2007mitiglinideon top insulin glargine -
Kaku, 2009mitiglinideplacebo (on top pioglitazone) -
nateglinide
Hanefeld, 1990nateglinideplacebo -
Goldberg, 1998repaglinideplacebo -
Horton, 2000nateglinideplacebo -
Jovanovic, 2000repaglinideplacebo -
Moses, 2001nateglinideplacebo -
Marre, 2002nateglinideplacebo Exploratory -
Saloranta, 2002nateglinideplacebo -
Bech, 2003repaglinideplacebo -
Mari, 2005nateglinideplacebo -
Ristic, 2006nateglinidegliclazide (add on MET) Exploratory -
Li, 2007nategliniderepaglinide -
Li, 2009nategliniderepaglinide -
pioglitazone
linagliptin 1264.3 ongoing linagliptin + pioglitazonepioglitazone - NCT01183013
repaglinide
Goldberg, 1998repaglinideplacebo Exploratory -
Moses, 1999repaglinidecontrol (add on MET) Exploratory -
Chuang, 1999repaglinideplacebo -
Landgraf, 1999repaglinideglibenclamide -
Marbury, 1999repaglinideglibenclamide -
Wolffenbuttel, 1999repaglinideglibenclamide -
Landin-Olsson, 1999repaglinideplacebo (on top bedtime NPH-insulin) -
Raskin, 2000repaglinideon top troglitazone -
Jovanovic, 2000repaglinideplacebo -
Madsbad, 2001repaglinideglipizide -
Raskin, 2001repaglinideon top rosiglitazone -
Raskin, 2001repaglinideon top pioglitazone -
Lund, 2007repaglinidemetformin -
saxagliptin
saxgliptin, renal studysaxagliptinplacebo (add on current treatment) -
saxagliptinsaxagliptinglipizide -
saxagliptin vs sitagliptinsaxagliptinsitagliptin (add on MET) -
CV181-011saxagliptinplacebo (monotherapy) - NCT00121641
CV181-038saxagliptinplacebo (monotherapy) - NCT00316082
CV181-057saxagliptinplacebo (add on insulin) - NCT00757588
CV181-066saxagliptinplacebo (add on MET) - NCT00683657
CV181-080saxagliptinplacebo (add on MET) - NCT00885378
CV181-085saxagliptin plus metformin XR 1500mgmetformin up to 2000mg - NCT00918138
Hollandersaxagliptinplacebo (add on TZD) - NCT00295633
CV181-040saxagliptin + glyburideglyburide uptitration - NCT00313313
CV181-041saxagliptinplacebo (monotherapy) - NCT00374907
Rosenstock, 2008saxagliptinplacebo (monotherapy) - NCT00950599
DeFronzo, 2009saxagliptinplacebo (add on MET)Negative NCT00121667
Jadzinsky, 2009saxagliptinplacebo (add on MET) - NCT00327015
Göke, 2010saxagliptin -
Scheen , 2010saxagliptin -
Stenlöf , 2010Saxagliptin -
Forst, 2011Saxagliptin -
Nowicki, 2011saxagliptin - NCT00614939
Yang, 2011saxagliptin - NCT00661362
Nowicki, 2011saxagliptin - NCT00614939
Kawamori, 2012saxagliptin - NCT00654381
Fonseca, 2012saxagliptin - NCT00960076
SAVOR-TIMI 53, 2013saxagliptinplaceboNegative NCT01107886
sitagliptin
Aschner, 2006sitagliptin monotherapyplaceboNegativeNCT00087516
Raz, 2006sitagliptin monotherapyplaceboNegative
Charbonnel, 2006sitagliptinplacebo (add on MET)NegativeNCT0086515
Rosenstock (sit on top pio vs pbo), 2006sitagliptinplacebo (on top PIO)SuggestingNCT00086502
Rosenstock , 2006sitagliptinplacebo (add on PIO) - NCT00086502
Goldstein, 2007sitagliptinplaceboNegativeNCT00103857
Hanefeld, 2007sitagliptinplaceboNegative
Scott* (sit vs pbo), 2007sitagliptin 50mg bid monotherapyplaceboNegative
Goldstein (sit vs met), 2007sitagliptinmetformin -
Scott* (sit vs glipi), 2007sitagliptin 50mg bid monotherapyglipizide -
Goldstein (sit+met vs met), 2007sitagliptinmetformin -
Hermansen, 2007sitagliptinplacebo (on-top glimepiride+/- metformine)Negative
Nauck, 2007sitagliptinplacebo (add on MET)NegativeNCT00094770
Scott** (sit vs pbo on top met), 2007sitagliptinplacebo (add on MET)Negative
Nonaka, 2008sitagliptin monotherapyplaceboNegativeNCT00371007
Chan, 2008sitagliptin monotherapyplacebo -
raz, 2008sitagliptinplacebo (add on MET) - NCT00337610
Mohan , 2009sitagliptin monotherapyplacebo -
Iwamoto , 2010sitagliptin monotherapyvoglibose -
Vilsbøll, 2010sitagliptinplacebo (add on insulin+/-MET) - NCT00395343
Aschner, 2010sitagliptin monotherapymetformin - NCT00449930
Derosa , 2010sitagliptin+piometformin+pio -
Rigby , 2010sitagliptinrosiglitazone (add on MET) -
Al Sifri, 2011sitagliptinSulphonylurea (on top MET) -
Pérez-Monteverde, 2011sitagliptinpioglitazone - NCT00541450
Stafford , 2011sitagliptin - NCT00451113
Barzilai, 2011sitagliptin monotherapyplacebo - NCT00305604
Reasner, 2011sitagliptincontrol (add on MET) - NCT00482729)
Arechavaleta, 2011sitagliptinglimepiride (add on MET) - NCT00701090
vildagliptin
NCT00101673vildagliptin - NCT00101673
CLAF237A 23104vildagliptin + METMET - NCT00396357
NCT00728351vildagliptinplacebo (add on MET) - NCT00728351
NCT00822211vildagliptinplacebo (add on MET) - NCT00822211
NCT00368134vildagliptinvoglibose - NCT00368134
NCT00351832vildagliptinplacebo - NCT00351832
NCT00494884 (Wollmer)vildagliptinplacebo (add on MET) - NCT00494884
NCT00396071vildagliptinplacebo (add on MET) - NCT00396071
Ahren, 2004vildagliptinplacebo (add on MET)Negative
Ristic, 2005vildagliptin monotherapyplaceboNegative
Mimori, 2006vildagliptinplacebo -
Pratley, 2006vildagliptin monotherapyplaceboNegative
Dejager [1], 2007vildagliptin monotherapyplaceboNegativeNCT00099905
Pi-Sunyer, 2007vildagliptin monotherapyplaceboSuggestingNCT00120536
Rosenstock* (vilda vs rosi), 2007vildagliptinrosiglitazone - NCT00099918
Rosenstock** (vilda vs pio), 2007vildagliptin monotherapypioglitazone - NCT00101803
Schweizer, 2007vildagliptinmetforminNegativeNCT00099866
Bosi, 2007vildagliptinplacebo (add on MET)NegativeNCT00099892
Fonseca, 2007vildagliptinplacebo (add on insulin)SuggestingNCT00099931
Garber, 2007vildagliptinplacebo (on top pioglitazone)NegativeNCT00099853
Rosenstock** (vilda + pio vs pio), 2007vildagliptinplacebo (add on TZD)NegativeNCT00101803
Scherbaum [2], 2008vildagliptinplaceboNegativeNCT00101712
Bolli, 2008vildagliptinpioglitazone (add on MET)NegativeNCT00237237
Goke, 2008vildagliptinmetformin -
Pan, 2008vildagliptin monotherapyacarbose - NCT00110240
Rosenstock, 2008vildagliptinplacebo - NCT00237250
Garber, 2008vildagliptinplacebo (add on SU) - NCT00099944
Fonseca , 2008vildagliptinplacebo (add on insulin) -
Ferrannini, 2009vildagliptinSulfonylurea (add on to MET) Exploratory SuggestingNCT00106340
Goodman, 2009vildagliptinplacebo (add on MET) Exploratory Negative
Filozof, 2009vildagliptingliclazide (add on MET) - NCT00102466
Foley, 2009vildagliptin monotherapygliclazide - NCT00102388
Schweizer, 2009vildagliptinmetformin - NCT00246619
Bosi, 2009vildagliptinplacebo (add on MET) - NCT00382096
GALIANT (Blonde), 2009vildagliptinTZD (add on MET) - NCT00396227
Kikuchi, 2009vildagliptin monotherapyplacebo -
Ahren, 2009vildagliptin monotherapyplacebo - NCT00390520
Rosenstock, 2009vildagliptinrosiglitazone - NCT00138619
Kikuchi, 2010vildagliptinplacebo (add on glimepiride) - NCT00325117
Matthews , 2010vildagliptinglimepiride (add on MET) -
Iwamoto, 2010vildagliptinvoglibose - NA
Foley, 2011vildagliptin monotherapyplacebo - NCT00260156
Lukashevich , 2011vildagliptinplacebo (add on current therapy) - NA



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