insulin sensitizer
Trials Results

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

diabetes type 2

aleglitazar
ALECARDIOaleglitazarplacebo - NCT01042769
BC22140 ongoing aleglitazarplacebo - NCT01042769
BC20265 ongoing aleglitazaractos - NCT00461058
metformin
UKPDS (vs SU or INS)metforminSU/InsulinSuggesting
Teupe, 1991metforminplaceboNegative
Campbell, 1994metforminGlipizideNegative
Kooy (HOME), 2009metforminplacebo Low risk of bias Suggesting
pioglitazone
PNFP-012pioglitazoneplacebo Exploratory Negative
PNFP-010pioglitazone + sulfonylureasulfonylurea Exploratory Negative
PNFP-014pioglitazone + insulinplacebo (add on insulin) Exploratory Negative
PNFP-027pioglitazone + metforminplacebo (add on MET) Exploratory Negative
PNFP-026pioglitazoneplacebo Exploratory Negative
OPI-502pioglitazone + insulinplacebo (add on insulin) Exploratory Negative
EC410pioglitazone + metforminsulfonylurea + metformin Exploratory Negative
OPI-504pioglitazonesulfonylurea Exploratory Negative NCT00521820
GLAIpioglitazonerosiglitazone Exploratory NegativeNCT00331487
PNFP-001pioglitazoneplacebo Exploratory Negative
EC405pioglitazonesulfonylurea Exploratory Negative
OPI-501pioglitazonesulfonylurea Exploratory Negative
EC404pioglitazonemetformin Exploratory Negative
EC409pioglitazone + sulfonylureametformin + sulfonylurea Exploratory Negative
OPI-520pioglitazonesulfonylurea Exploratory NegativeNCT00521742
OPI-506pioglitazonesulfonylurea Exploratory NegativeNCT00494312
PROactive, 2005pioglitazoneplacebo Low risk of bias Suggesting NCT00174993
PERISCOPE, 2008pioglitazoneglimepiride Exploratory NegativeNCT00225277
Bolli, 2008pioglitazonevildagliptinNegative
PPAR ongoing pioglitazonestandard glucose-lowering drugs - NCT00212004
TIDE ongoing rosiglitazone pioglitazoneplacebo Low risk of bias - NCT00879970
rosiglitazone
AVM100264 rosiglitazone Exploratory - NCT00359112
BRL 49653C/185 rosiglitazone Exploratory -
BRL 49653/334 rosiglitazoneplacebo Exploratory - NCT00306644
BRL 49653/347 rosiglitazoneplacebo (add on insulin) Exploratory - NCT00054782
49653/015 rosiglitazoneplacebo (add on SU) Exploratory -
49653/079 rosiglitazoneglyburide Exploratory -
49653/080 rosiglitazoneglyburide Exploratory -
49653/085 rosiglitazoneplacebo (add on insulin) Exploratory -
49653/095 rosiglitazoneplacebo (add on insulin) Exploratory -
49653/097 rosiglitazoneglyburide Exploratory -
49653/125 rosiglitazoneplacebo (add on SU) Exploratory - NCT00422955
49653/127 rosiglitazoneplacebo (add on glyburide) Exploratory -
49653/128 rosiglitazoneplacebo Exploratory -
49653/134 rosiglitazoneplacebo Exploratory -
49653/135 rosiglitazoneplacebo (add on glipizide) Exploratory -
49653/136 rosiglitazoneplacebo Exploratory -
49653/145 rosiglitazoneplacebo (add on glicazide) Exploratory -
49653/147 rosiglitazoneplacebo (add on SU) Exploratory -
49653/162 rosiglitazoneplacebo (add on glyburide) Exploratory -
49653/234 rosiglitazoneplacebo (add on glimepiride) Exploratory -
49653/330 rosiglitazoneplacebo Exploratory -
49653/331 rosiglitazoneplacebo Exploratory -
49653/137 rosiglitazoneglyburide (add on MET) Exploratory - NCT00500955
SB-712753/002 rosiglitazoneplacebo (add on MET) Exploratory -
SB-712753/003 rosiglitazoneplacebo (add on MET) Exploratory -
SB-712753/009 rosiglitazone Exploratory -
49653/132 rosiglitazoneplacebo (add on SU) Exploratory -
AVA100193 rosiglitazoneplacebo Exploratory -
49653/011 rosiglitazoneplacebo Exploratory -
49653/020 rosiglitazoneglyburide Exploratory -
SB-712753/007 rosiglitazone Exploratory -
49653/093 rosiglitazonemetformin Exploratory -
49653/094 rosiglitazonemetformin Exploratory -
100684 rosiglitazoneplacebo (add on glyburide) Exploratory - NCT01045590
49653/143 rosiglitazoneglyburide Exploratory - NCT00333723
49653/211 rosiglitazoneusual care Exploratory -
49653/284 rosiglitazoneplacebo (add on MET) Exploratory - NCT00501020
712753/008 rosiglitazoneplacebo (add on MET) Exploratory - NCT00241605
Wang, 2005rosiglitazonecontrol Exploratory -
ADOPT, 2006rosiglitazonestandard glucose-lowering drugs Exploratory NegativeNCT00279045
APPROACH, 2008rosiglitazoneglipizide Exploratory - NCT00116831
RECORD, 2009rosiglitazonestandard glucose-lowering drugs Risk of bias Negative NCT00379769



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