direct factor Xa inhibitors
Trials Results

  • Group by...

TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009apixabanplacebo Exploratory Negative NCT00313300
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNegativeNCT00313300
APPRAISE 2, 2011apixabanplacebo Low risk of bias Negative NCT00831441
APPRAISE japan ongoing apixabanplacebo Exploratory - NCT00852397
dabigatran
REDEEM, 2009dabigatranplaceboNegativeNCT00621855
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparin Exploratory SuggestingNCT00317395
rivaroxaban
ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNegative NCT00402597
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNegativeNCT00402597
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplacebo Low risk of bias Suggesting NCT00809965
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboSuggesting NCT00809965
ximelagatran
ESTEEM, 2003ximelagatranplacebo Exploratory -

atrial fibrillation

apixaban
phase 2 apixabanapixabanwarfarin standard dose Exploratory - NCT00787150
AVERROES, 2011apixabanaspirinineligible for VKA Low risk of bias Suggesting NCT00496769
ARISTOTLE, 2011apixabanwarfarin standard dose Low risk of bias ConclusiveNCT00412984
edoxaban
phase 2 edoxabanedoxabanwarfarin standard dose Exploratory - NCT00806624
Weitz (edoxaban phase 2)edoxabanwarfarin standard dose Exploratory - NCT00504556
ENGAGE-AF TIMI 48 High dose, 2013edoxaban high dosewarfarin standard dose Low risk of bias Suggesting NCT00781391
rivaroxaban
ROCKET-AF, 2010rivaroxabanwarfarin standard dose Low risk of bias Suggesting NCT00403767
ROCKET J ongoing rivaroxabanwarfarin standard dose - NCT00494871

cardiovascular prevention

rivaroxaban
COMPASS (rivaroxaban + aspirin), 2017rivaroxaban + aspirinaspirinsecondary prevention Low risk of bias - NCT01776424
COMPASS (rivaroxaban alone), 2017rivaroxabanaspirinsecondary prevention - NCT01776424

thrombosis prevention

apixaban
APROPOS 2.5mg, 2007apixabanenoxaparin (US regimen)knee surgery Exploratory NegativeNCT00097357
ADVANCE-1, 2008apixabanenoxaparin (US regimen)knee surgery Low risk of bias SuggestingNCT00371683
ADVANCE 3, 2010apixabanenoxaparinhip surgery Low risk of bias SuggestingNCT00423319
ADVANCE 2, 2010apixabanenoxaparin (europe regimen)knee surgery Low risk of bias SuggestingNCT00452530
edoxaban
STARS J-Vedoxabanenoxaparin (short duration)hip surgery Low risk of bias SuggestingNCT01181167
DU176b-B-J302 ongoing edoxabanenoxaparinknee surgery - NCT01181102
DU176b-B-J303 ongoing edoxabanenoxaparinhip surgery - NCT01181141
DU176b-B-J304 ongoing edoxabanenoxaparinhip surgery - NCT01181167
DU176b-04 ongoing edoxabanplaceboknee surgery - NCT01203072
rivaroxaban
ODIXa-KNEE, 2005rivaroxabanenoxaparin (US regimen)knee surgery Exploratory Negative
ODIXa-HIP 10mg, 2006rivaroxabanenoxaparin (short duration)hip surgery Exploratory Suggesting
RECORD 3, 2008rivaroxabanenoxaparin (europe regimen)knee surgery Low risk of bias SuggestingNCT00361894
RECORD 2, 2008rivaroxaban (long duration)enoxaparin (short duration)hip surgery Low risk of bias SuggestingNCT00332020
RECORD 1, 2008rivaroxabanenoxaparinhip surgery Low risk of bias SuggestingNCT00329628
RECORD 4, 2009rivaroxabanenoxaparin (US regimen)knee surgery Low risk of bias SuggestingNCT00362232

venous thrombosis

ximelagatran
THRIVE III, 2003ximelagatrandiscontinuation Low risk of bias Suggesting



- About - Browse pathology | treatment - Site map - Credits Made with in Lyon - Contact us - Privacy policy - Licence Creative Commons