vasodilators therapy
Trials Results

Buflomedil - Epoprostenol

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TrialStudied treatmentControl treatmentpatientsROBResultNCT

heart failure

epoprostenol
FIRST, 1997epoprostenolstandard care Exploratory -
hydralazine
Chatterjee, 1980hydralazinecontrol Exploratory -
Franciosa, 1982hydralazineplacebo Exploratory -
Magorien , 1984hydralazineplacebo Exploratory -
Conradson , 1984hydralazineplacebo Exploratory -
hydralazine-ISDN
VHeFT I (hydralazine ISDN), 1986hydralazine-ISDNplacebo Low risk of bias Negative
isosorbide dinitrate
Franciosa , 1978isosorbide dinitrateplacebo Exploratory -
NICE (Lewis), 1999isosorbide dinitrateplacebo -
nesiritide
NSGET (efficacy trial), 2000nesiritideplacebo Low risk of bias Negative
NSGET (comparative trial), 2000nesiritidecontrol Low risk of bias -
PRECEDENT, 2002nesiritidedobutamine Exploratory - NCT00270400
VMAC (24h), 2002nesiritidenitroglycerin Risk of bias NegativeNCT00083772
VMAC (intravenous neseritide), 2002nesiritideplacebo Low risk of bias - NCT00083772
PROACTION, 2003nesiritideplacebo Low risk of bias Negative
FUSION 1, 2004nesiritidestandard care Low risk of bias - NCT00270361
BNP-CARDS, 2007nesiritideplacebo Exploratory - NCT00186329
FUSION 2, 2008nesiritideplacebo Low risk of bias - NCT00091520
ASCEND-HF, 2011nesiritideplacebo Low risk of bias Negative NCT00475852

peripheral vascular diseases

buflomedil
Diamantopoulos, 2001buflomédilplacebo -
LIMB, 2008buflomedilplacebo Low risk of bias Suggesting
cilostazol
Otsuka 21-95-201cilostazolplacebo -
Dawson, 1998cilostazolplacebo -
Money, 1998cilostazolplacebo -
Elam, 1998cilostazolplacebo -
Beebe, 1999cilostazolplacebo -
Dawson (cilostazol), 2000cilostazolplacebo -
Strandness, 2002cilostazolplacebo -
ginko biloba
Bauer, 1984ginko bilobaplacebo -
Peters, 1998ginko bilobaplacebo -
naftidrofuryl
Clyne, 1980naftidrofurylplacebo -
Meehan, 1982naftidrofuryl IVcontrol -
Negus, 1987naftidrofuryl IVprostacyclin -
Testart, 1994naftidrofuryl IVplacebo -
NIQOL germany, 1999Naftidrofurylplacebo -
D'Hooge D, 2001naftidrofuryl IVplacebo -
NCIS, 2001naftidrofurylplacebo -
NIQOL belgium, 2001naftidrofurylplacebo -
pentoxifylline
Porter, 1982pentoxifyllineplacebo -
Donaldson, 1984pentoxifyllineplacebo -
APIC, 1989pentoxifyllineplacebo -
Dawson (pentoxifylline), 2000pentoxifyllineplacebo -
Belcaro, 2002pentoxifyllineplacebo -



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