calcium channel blockers

Amlodipine - Diltiazem - Diltiazem - Felodipine - Nicardipine - Nidrendipine - Nifedipine - Nisoldipine - Verapamil

TrialStudied treatmentControl treatmentpatientsROBResultNCT

acute coronary syndrome

diltiazem
DRS, 1986diltiazemplacebo -
Göbel (Dutch study), 1995diltiazemplacebo -
nifedipine
HINT (nifedipine vs metoprolol), 1988nifedipinemetoprolol -

acute myocardial infarction

diltiazem
Machecourt, 1986diltiazemNegative
Gibson, 1986diltiazemplaceboNegative
Zannad, 1988diltiazemplaceboNegative
MDPIT, 1988diltiazemplaceboNegative
nifedipine
MI study group, 1979nifedipine -
Muller, 1984nifedipineNegative
Gordon, 1984nifedipineNegative
Sirnes, 1984nifedipineplaceboNegative
Loogna, 1985nifedipineplaceboNegative
Eisenberg, 1985nifedipineplaceboNegative
TRENT (Wilcox), 1986nifedipineplaceboNegative
Bradagan, 1986nifedipineplaceboNegative
Jaffe, 1987nifedipineplaceboNegative
Walker, 1988nifedipineplaceboNegative
Erbel, 1988nifedipineplaceboNegative
SPRINT I, 1988nifedipineplaceboNegative
Gottlieb, 1988nifedipineplaceboNegative
SPRINT II, 1993nifedipineplaceboNegative
verapamil
DAVIT I, 1984verapamilplacebo -
Bussman, 1984verapamilcontrolNegative
Danish study, 1984verapamilplaceboNegative
Crea, 1985verapamilplaceboNegative
DAVIT II, 1990verapamilplaceboNegative
CRIS, 1996verapamilplaceboNegative

heart failure

amlodipine
Packer, 1991amlodipinecontrol Exploratory -
Smith, 1994amlodipinecontrol Exploratory -
Binkley, 1996amlodipinecontrol Exploratory -
PRAISE, 1996amlodipineplacebo Low risk of bias Negative
Udelson, 1996amlodipinecontrol Exploratory -
Ghali, 1997amlodipinecontrol Exploratory -
PRAISE II , 2000Amlodipineplacebo Low risk of bias Negative
diltiazem
DiDi, 1996diltiazemplacebo Low risk of bias Negative
Liao , 1998Diltiazemplacebo Exploratory Suggesting
felodipine
Kassis, 1987felodipineplacebo Exploratory -
Kassis, 1990felodipineplacebo Exploratory -
Dunselman, 1990felodipineenalapril Exploratory -
De Vries, 1995felodipineenalapril Exploratory -
Littler, 1995Felodipineplacebo Exploratory Negative
VHeFT III, 1997felodipineplacebo Exploratory Negative
isradipine
Van den Toren, 1996isradipineplacebo Exploratory -
mibefradil
MACH 1, 2000mibefradilplacebo Low risk of bias Suggesting
nicardipine
Gheorghiade, 1991nicardipinecontrol Exploratory -
Abrams, 1993nicardipinecontrol Exploratory -
nisoldipine
Schofer, 1990nisoldipinecaptopril Exploratory -
Rousseau, 1994nisoldipineplacebo Exploratory -
Gaudron, 1996Nisoldipineplacebo Exploratory -

post myocardial infarction

diltiazem
MDPIT, 1988diltiazemplaceboNegative
nifedipine
MI study group, 1979nifedipine -
SPRINT I, 1988nifedipineplaceboNegative
SPRINT II, 1993nifedipineplaceboNegative
verapamil
DAVIT I, 1984verapamilplacebo -
Danish study, 1984verapamilplaceboNegative
DAVIT II, 1990verapamilplaceboNegative
CRIS, 1996verapamilplaceboNegative