carotid stenosis clinical trials results

carotid artery stenting versus medical treatment
SAMMPRIS, 2011 NCT00576693	aggressive medical management plus percutaneous transluminal angioplasty and stenting versus aggressive medical management alone	patients who had a recent transient ischemic attack or stroke attributed to stenosis of 70 to 99% of the diameter of a major intracranial artery	open Follow-up duration: 11.9 months
carotid artery stenting versus surgery
Leicester (Naylor), 1998	Self-expanding Wallstent versus surgery	patients with focal carotid territory symptoms and severe ICA stenosis (> 70%)	open Follow-up duration: 1 month
WALLSTENT (Alberts), 2001	Wallstent versus		open Follow-up duration: 12 months
CAVATAS-CEA, 2001 ISRCTN01425573	Pre-1994: PTA only after 1994: Wallstent, Streker, Palmaz versus carotid endarterectomy	patients of any age with symptomatic or asymptomatic carotid artery stenosis suitable for surgery	open Follow-up duration: 36 months (4y)
Kentucky A (Brooks), 2001	Wallstent versus surgery	patients presenting with cerebrovascular ischemia ipsilateral to carotid stenosis	open Follow-up duration: 48 months
Kentucky B (Brooks), 2004	Wallstent, Dynalink versus carotid endarterectomy	patients with asymptomatic carotid stenosis of more than 80% were selected	open Follow-up duration: 48 months
SAPPHIRE (yadav), 2004	Smart or Precise (self-expanding nitinol stent)age/pj versus surgery	patients with coexisting conditions that potentially increased the risk posed by endarterectomy and who had either a symptomatic carotid-artery stenosis of at least 50 percent of the luminal diameter or an asymptomatic stenosis of at least 80 percent	open Follow-up duration: 36 months
EVA-3S (Mas), 2000	various stent versus endarterectomy	patients with a symptomatic carotid stenosis of at least 60%	open Follow-up duration: 6 months
SPACE, 2000	carotid-artery stenting (Carotid Wallstent; Precise; Acculink) versus Carotid endarterectomy	patients with symptomatic carotid-artery stenosis within 180 days of transient ischaemic attack or moderate stroke (modified Rankin scale score of < or =3)	open Follow-up duration: 1 month
TESCAS-C (Ling), 2006	versus		open Follow-up duration: 6 months
BACASS (Hoffman), 2006	stent versus CEA	patients with symptomatic carotid stenosis > 70%	open Follow-up duration: 45 months
Steinbauer, 2008	carotid artery stenting versus Carotid endarterectomy		Follow-up duration: 65 months
ICSS, 2010 ISRCTN25337470	carotid artery stenting versus endarterectomy	patients with symptomatic carotid stenosis of greater than 50% within last six months	open Follow-up duration: 120 days Europe, Autralia, New Zealand, Canada
CREST, 2010 NCT00004732	carotid artery stenting (with distal-protection) versus carotid endarterectomy	patients with both asymptomatic and symptomatic extracranial carotid stenosis	open Follow-up duration: 2.5y US, Canada
carotid endarterectomy versus control
ACST, 1994	CEA as soon as possible, standard medical treatment including antiplatelet drugs versus no CEA unless symptoms occurred, standard medical treatment including antiplatelet drugs	Asymptomatic carotid artery stenosis of 60% or greater	open Follow-up duration: 3.4y mean Europe
VA, 1993	carotid endarterectomy aspirin 650 mg bd versus aspirin 650 mg bd	Asymptomatic carotid artery stenosis of 50-99%	open Follow-up duration: 4 y (mean) US
ACAS, 1995	carotid endarterectomy, aspirin 325 mg daily versus aspirin 325 mg daily	Asymptomatic carotid artery stenosis of 60% or greater	open Follow-up duration: 2.7 y mean North America
ECST, 1998	surgery versus control	men and women of any age, with some degree of carotid stenosis, who within the previous 6 months had had at least one transient or mild symptomatic ischaemic vascular event in the distribution of one or both carotid arteries	open Follow-up duration: 6.1 years
NASCET, 1998	carotid endarterectomy versus medical care alone	Patients with moderate (<70%) carotid stenosis and transient ischemic attacks or nondisabling strokes on the same side as the stenosis (ipsilateral) within 180 days	open Follow-up duration: 5 years
VA309, 1991	Carotid endarterectomy plus the best medical care versus best medical care alone	Men who presented within 120 days of onset of symptoms that were consistent with transient ischemic attacks, transient monocular blindness, or recent small completed strokes and with with angiographic internal carotid artery stenosis greater than 50% ipsilateral to the presenting symptoms	open Follow-up duration: 11.9 months