systematic review meta-analysis network meta-analysis
 

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathstroke (fatal and non fatal)

cardiovascular prevention  

WAVE, 2002      NCTcombined estrogen and progestogenplaceboLow risk of bias negative78%76%
EAGAR, 2006      NCTcombined estrogen and progestogenplaceboLow risk of bias negative -46%
HERS, 1998          NCTcombined estrogen and progestogenplaceboLow risk of bias negative 6%11%
EVTET, 2000     combined estrogen and progestogenplaceboLow risk of bias negative
Hall, 1998     combined estrogen and progestogenplaceboLow risk of bias negative-100%∞%
WHI, 2002       combined estrogen and progestogenplaceboLow risk of bias negative 1%42%
WHISP, 2006     combined estrogen and progestogenplaceboLow risk of bias negative-100%-100%
WISDOM, 2007     combined estrogen and progestogenplaceboLow risk of bias negative 59%-27%
ERA (estrogen plus medroxyprogesterone), 2000      NCTcombined estrogen and progestogenplaceboLow risk of bias negative-50%1%
WELL-HART (estrogen-progestin), 2003      NCTcombined estrogen and progestogenplaceboLow risk of bias negative-23%
Schulman (NHLBI) (estrogen-progestogen), 2002      NCTcombined estrogen and progestogenplaceboLow risk of bias -
Marmorstein, 1962   estrogenplaceboLow risk of bias -
Stamler, 1963   estrogenplaceboLow risk of bias -
VA Neurology Section (estrogen), 1966   estrogenplaceboLow risk of bias -
CDP estrogen 5, 1975   estrogenplaceboLow risk of bias -
CDP estrogen 2.5, 1975   estrogenplaceboLow risk of bias -
ERA (estrogen alone ), 2000        NCTestrogenplaceboLow risk of bias negative40%-13%
WELL-HART (estrogen alone), 2003      NCTestrogenplaceboLow risk of bias negative-50%
Schulman (NHLBI) (estrogen alone), 2002      NCTestrogenplaceboLow risk of bias -
EPAT, 2001     estrogenplaceboLow risk of bias negative-100%∞%
ESPRIT, 2002     estrogenplaceboLow risk of bias negative-19%64%
WEST, 2001     estrogenplaceboLow risk of bias negative14%9%
VA drugs (Estrogen or thyroxine), 1968   estrogen or thyroxineplaceboLow risk of bias suggesting-61%



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