diuretics

systematic review meta-analysis network meta-analysis

Select acute heart failureheart failure All type of patientelderly patientsLeft Ventricular Dysfunction after Myocardial Infarctionpatients already taking diureticspatients with preserved-LVEF heart failure       adenosine A1 receptor antagonistaldosterone-receptor blockersdeviceDiureticsmineralocorticoid receptor antagonistsselective adenosine-1 receptor antagonist amilorideeplerenonefurosemidehydrochlorothiazide rolofylline spironolactonetonapofylline vs placebo or controlvs active treatment      

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Group by Group by... nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition MA  in first nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in second nothing pathology treatment patient comparator classe classe comparator mechanism clinical condition  in third	Description Synopsis Comparison Treatments Patients Characteristics Method Risk of bias References None Tools Indexation					Results Global trial result Main results All results All result tag NCT results	exacerbation of heart failure (9)All cause death (6)NYHA class improvement (4)Cardiovascular death (3)Adverse events (3)serious hyperkalemia (3)Sudden death (3)hospitalisation for cardiovascular causes (2)Adverse events leading to treatment discontinuation (1)Death from any cause or hospitalization for heart failure (1)Hospitalization for any reason (1)hospitalisation for heart failure (1)Death from any cause or hospitalization for any reason (1)death from cardiovascular causes or hospitalization for cardiovascular causes (1) Options Numeric bar chart forest plot medians
Trial	Studied trt	Control trt	patients	tags	ROB	Trial result	exacerbation of heart failure	All cause death
acute heart failure
rolofylline
PROTECT, 2010    NCT	rolofylline	placebo			Low risk of bias	negative
heart failure
amiloride
Cheitlin, 1991	amiloride	placebo			Low risk of bias	-
eplerenone
EMPHASIS-HF, 2010        NCT	eplerenone	placebo			Low risk of bias	suggesting
EPHESUS, 2003	eplerenone	placebo			Low risk of bias	suggesting
furosemide
Boccanelli, 1986	furosemide	captopril			Low risk of bias	negative
Cowley, 1986	furosemide	captopril			Low risk of bias	-
hydrochlorothiazide
Nordrehaug, 1992	hydrochlorothiazide	benazepril			Low risk of bias	suggesting
Sievert, 1989	hydrochlorothiazide+triamterene	digoxin			Low risk of bias	-
rolofylline
PROTECT-1    NCT	rolofylline	placebo				-
spironolactone
Cicoira, 2004	spironolactone	control				-
Cicoira, 2002	spironolactone	control			Exploratory	-
Ramires, 2000	spironolactone	control			Exploratory	-
RALES, 1998	spironolactone	placebo			Risk of bias	suggesting
Agostoni, 2005	spironolactone	placebo			Exploratory	-
Mottram, 2004	spironolactone	placebo			Low risk of bias	-
Macdonald, 2004	spironolactone	placebo			Low risk of bias	-
Yee, 2001	spironolactone	placebo			Low risk of bias	-
Tsutamoto, 2001	spironolactone	placebo			Low risk of bias	-
Farquharson, 2000	spironolactone	placebo			Low risk of bias	-
MacFadyen, 1997	spironolactone	placebo			Low risk of bias	-
Barr, 1995	spironolactone	placebo			Low risk of bias	-
Han, 1994	spironolactone+captopril	captopril			Exploratory	-
Bednarz, 2000	aldactone	furosemide			Exploratory	-
Dalhstrom, 1986	furosemide + spironolactone	prenalterol			Low risk of bias	negative
Mauersberger, 1985	spironolactone+furosemide	spironolactone+butizide			Exploratory	-